Denosyl^® is a liver and brain health supplement for dogs and cats containing S-Adenosylmethionine (SAMe).

When liver function is compromised, the exact cause can often be difficult to determine. Supporting the liver, regardless of the cause, is essential if function is to be improved.

Denosyl^® is now available in chewable tablets (for dogs)

• Contains exclusive stable NMXSS75™ S-Adenosylmethionine (SAMe)
• Advanced technology in NMXSS75 SAMe provides stability eliminating the need for enteric coating or foil-on-foil blistering
• Quicker absorption of SAMe when compared to regular hard tablets
• Designed as palatable, single size, scored chewable tablets for easy administration

Denosyl has been shown to markedly increase liver glutathione levels,^1,2 a potent antioxidant formed when cats and dogs metabolize SAMe. Denosyl has also been shown to help protect liver cells from cell death^3,4 and may help cell repair and regeneration.⁵

Research is looking into dog aging and associated decreases in levels of S-Adenosylmethionine (SAMe) in cerebrospinal fluid, which surrounds the brain. Age related brain issues include confusion or personality changes often expressed through being less social. Denosyl provides SAMe in a stablized form to help with brain health and act as a neuroprotector.

Liver Function in Animals

The liver participates in a lot of activities within the body. It helps the digestion of food through production of bile and helps change digested foods into substances used by the body for energy and growth. The liver also helps process some medications into material(s) that can be used by the body; the liver may assist in eliminating medications from the body once they have had their effect. The liver stores vitamins and minerals and works with sugar (carbohydrates, glucose), fats and proteins. It also helps maintain proper blood clotting and removes many body toxins from the blood. Without proper liver function, the pet's health is compromised.

Because it does so much, the liver may be subject to injury, both direct and indirect. Some of the signs may include: weakness, vomiting, poor appetite, and/or seizures. If you notice any of these signs or your pet is just acting differently, you should contact your veterinarian. Many veterinarians run screening tests for middle aged and older patients during the annual examination to ensure that organ function is normal.

Nutramax Laboratories, Inc. currently makes three products for liver support: Denosyl^®, Marin^®, and Denamarin^®.

90 mg for cats and small dogs 225 mg for medium dogs 13-34 lbs 425 mg for large dogs 35 lbs and over

for cats for small and medium dogs 35 lbs and under for large dogs over 35 lbs

These products support the liver through differing actions and may be used individually or in combination depending on your pet’s needs. To find out more, click below to download or print the brochure on each of these products. Or, just ask your vet!

Download Marin Brochure
Download Denosyl Brochure
See Research



REFERENCES

1. Center SA, Warner K, Hoffman WE, et al. Am J Vet Res 2005;66:330-341.
2. Center SA, Randolph JF, Warner K, et al. J Vet Intern Med 2005;19:303-314.
3. Webster CRL, Boria P, Usechak P, et al. Vet Therapeutics 2002;3:474-484.
4. McCool J, Johnston A, Webster CRL. In Proceedings. 21st Annual ACVIM Forum 2003;abstract #134.
5. Center SA. In Proceedings. 18th Annual ACVIM Forum 2000;550-552.